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Dopamine agonists


By Serge Kreutz (2004)

Dopamine agonists have been around for many decades, and their pro-libido effect is well established. Apart from Dostinex, the assortment of dopamine agonists includes bromocriptine, pergolide, pramipexole, lisuride, apomorphine, and a few more.

Actually, apomorphine (brand name: Uprima) was sold in Europe as a medication for erectile dysfunction. But it was wrong marketing. Dopamine agonists don't work for erections as reliably as phosphodiesterase inhibitors. They work, if at all, on libido. Therefore, Uprima typically was a disappointment for men whose problems are primarily vascular. I assume that Uprima was sold as a medication for erectile dysfunction mainly because erectile dysfunction meanwhile is an accepted medical condition, while low libido is not.

I have been using dopamine agonists for sexual enhancement. And not only dopamine agonists.

To summarize my observation: while sildenafil citrate and yohimbine work on erections, and while elevating testosterone levels only is of a pro-sexual nature if it is done with tongkat ali extract, dopamine agonists can be used, on a limited scale, for enhancing sexual excitement, orgasm, and ejaculation.

Because dopamine agonists suppress the hormone prolactin, which in turn suppresses testosterone, dopamine agonists can, in people with elevated prolactin levels, function in the same way as a testosterone replacement therapy would. This most clearly happens in patients with pituitary cancer, which typically expresses itself in strongly elevated prolactin levels. Those afflicted by the disease have very low testosterone levels. Thus, for them, Dostinex and other dopaminergic agents work as hormonal therapy. The hormonal effects of Dostinex are less extreme in healthy subjects.

Dopamine agonists not only support sexual excitement; they also tend to enhance orgasm and make for a stronger ejaculation, though the ejaculation-enhancing effect is greater with tongkat ali, which can account for an additional half meter in ejaculatory range (and ejaculations on tongkat ali can feel like pellets, not fluid, moving through the urethra). Orgasms in general will be much more overwhelming.

But dopamine agonists also have their downsides. All the older ones can cause nausea. I myself cannot take L-dopa or lisuride. Nausea on these drugs is so severe that I want to see a nurse, rather than a girl, and only for medical purposes.


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Copyright Serge Kreutz